Question: I am suffering from an extreme bout of depression for the last 16 months. It came on one day out of the blue. I am retired from a successful career, have a loving supportive family and friends. This is not my first case of mdd. I have been on medication since 1991 and have been able to function and work for 33 years. My main symptom is severe fatigue. I am bedbound at least 20 hours/ day. I cannot take a shower without 2 hrs of exhaustion. Again this just started one day no gradual decline. I have a wonderful psychiatrist who is at her wits end. She has tried me on every known antidepressant. I was on effexor for 10 years until it totally stopped working. Then the guessgame of one drug after another started. I try them all for at least 8 weeks to no avail. Right now I am on 60 mg of seratraline , 2 Mgs of klonopin and 30 Mgs of buspar. I tried rittalin which made me jump out of my skin. To be truthful the only thing that made me feel better was oxycodone for my 3 ruptured discs in my back. But I know I can't take it on a regular basis. One doctor thought I had chronic fatigue syndrome and wanted to add valtrex. I had gastric bypass 12 yrs ago and worry about stomach problems. I also don't think I absorb meds like normal although had a heck of a time coming off effexor. I even had my gallbladder out as I was told this could cause fatigue. That was a year ago with no change. I have had my thyroid tested several times as thyroid disease is rampant in my family. Again told normal except for nodules that are benign. I know I Ned to exercise but I can hardly walk and tend to pass out. My bd is sometimes low and sometimes normal. Nothing seems to raise it. I've also tried every supplement and meditation. I want to make it to my daughters wedding in August but on a daily basis sometimes I feel like I may commit suicide before then if things get worse. Do yo have anything I could advise my psychiatrist and would it be worth it to spend thousands of dollars on a chronic fatigue clinic? Thanks for any help.