Question: my daughter was recently on voraconazole firstly for candida, then posaconazole, then IV fluconozole and IV amphotericin B over the course of three months. She was also on IV Cefepime, IV ciproflaxicin, norfloxicin, IV teicoplanin, prednisone, zoton, amlodipine, lisinopril, maxalon, ondansatron and many other medications at the same time as the antifungals. My questions are these: Can voriconazole predispose people to mucor infection (which is the fungus the grew firstly in her urine and then in her blood culture) following a course of Voriconazole. She ended up in renal failure following three days of 200mg QID posaconazole which had been a follow on course of antifungals after three days of amphotericin B 5mg/kg/day with no congenital cause. I am wondering if the combination of all of these medications could cause acute renal injury. Finally, with that combination of antifungals and antibiotics and immune suppressants could that possibly cause polymicrobial growth in blood? She has a specific antibody deficiency, with neutrophil and innate system dysfunction. She had many side effects from these medications, including, nausea, vomiting, headache and peeling skin.

thank you.

Could three days of posaconazole following three days of amphotericin cause acute renal failure?

Could the combination of high dose steroids, antibiotics and antifungals place an immune deficient child at risk of polymicrobial (candida and mucor) blood infection.
At the time of infection, she had not received any antifungals for 48 hours.