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Suggest Treatment For Persistent Knee Pain

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Posted on Thu, 20 Apr 2017
Question: i used ultram very successsfully for knee pain before replacement. now ive been using using hydrocodone/acetaminophen 10325 325MGfor a while and less effective. the use is for both shoulder needing replacement and discs betweenL vertabrea L 2 &3 and L4 &5 pr0blems, questions if i take minimum zoloft can i safely go back to ultram YYYY@YYYY
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Answered by Dr. Dr. Matt Wachsman (5 hours later)
Brief Answer:
cannot predict the future but

Detailed Answer:
Serotonin syndrome is just not very common. Seizure risk is even lower unless you are prone to seizures and it wouldn't be higher than when you took it before.

BUT, individuals vary and one cannot guarantee what will happen in your particular case.

I can, however, also mention that the drug interactions require the drug to be there. The peak levels of drugs lasts 1-2 hrs. the duration of hydrocodone is about 4 hrs, so if there were an interaction it would not be expected to last as long as the usual wait to be seen in the ER.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Dr. Matt Wachsman

Addiction Medicine Specialist

Practicing since :1985

Answered : 4214 Questions

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Suggest Treatment For Persistent Knee Pain

Brief Answer: cannot predict the future but Detailed Answer: Serotonin syndrome is just not very common. Seizure risk is even lower unless you are prone to seizures and it wouldn't be higher than when you took it before. BUT, individuals vary and one cannot guarantee what will happen in your particular case. I can, however, also mention that the drug interactions require the drug to be there. The peak levels of drugs lasts 1-2 hrs. the duration of hydrocodone is about 4 hrs, so if there were an interaction it would not be expected to last as long as the usual wait to be seen in the ER.