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Taking Immunoglobulin Replacement Therapy For Low IgG1 And IgG3. Had Anthrax Vaccine. Will Immunization Cause Multiple Illness?
Question: Hello - I have low IgG1 and IgG3 - and have started immunoglobulan replacement therapy... I am quite unwell as you can see from my Medical History, this all seemed to happen after an immunisation.
Q/ Have you ever seen immunization cause multiple illness?
Q/ What diseases can cause low IgG1 and IgG3 and what medications (see mine below)?
Q/ It feels like my immune system is on overdrive and is now burnt out, could something be in my blood that causes this issue, I did have the Antrax vaccine and I am ex military - but you cant test for squalene antibody in this country (Australia).
Q/ I need treatment for Autoimmune Arthritic Diseases and at the same time I need replacement IgG - what drugs would be best for me to treat the arthritis, it seems I need to turn off the immune system and turn it on at the same time?
Q/ I had antiretrovirals for 4 weeks - could these have screwed my blood up?
Q/ Looking at my medical history, is there anything you would suggest testing for with bloodwork?
Q/ Have you ever seen immunization cause multiple illness?
Q/ What diseases can cause low IgG1 and IgG3 and what medications (see mine below)?
Q/ It feels like my immune system is on overdrive and is now burnt out, could something be in my blood that causes this issue, I did have the Antrax vaccine and I am ex military - but you cant test for squalene antibody in this country (Australia).
Q/ I need treatment for Autoimmune Arthritic Diseases and at the same time I need replacement IgG - what drugs would be best for me to treat the arthritis, it seems I need to turn off the immune system and turn it on at the same time?
Q/ I had antiretrovirals for 4 weeks - could these have screwed my blood up?
Q/ Looking at my medical history, is there anything you would suggest testing for with bloodwork?
Brief Answer:
Dysgammaglobulinemia
Detailed Answer:
Hi,
Thanks for your query.
My answers to your questions are as below.
Q/ Have you ever seen immunization cause multiple illness?
--No, but its possible and very rare.
Q/ What diseases can cause low IgG1 and IgG3 and what medications (see mine below)?
-- Most common cause for such Dysgammaglobulinemia is genetic. Some infections and bone marrow diseases can also cause the same.
Q/ It feels like my immune system is on overdrive and is now burnt out, could something be in my blood that causes this issue, I did have the Antrax vaccine and I am ex military - but you cant test for squalene antibody in this country (Australia).
--Yes, it can happen as you suspect. It is very difficult to identify the culprit.
Q/ I need treatment for Autoimmune Arthritic Diseases and at the same time I need replacement IgG - what drugs would be best for me to treat the arthritis, it seems I need to turn off the immune system and turn it on at the same time?
--This is a difficult scenario. Cell specific immune modulators are the ones you can opt for. These do not inhibit the immune cells in toto but a single group of cells which could be involved in the autoimmune process affecting the joints.
Q/ I had antiretrovirals for 4 weeks - could these have screwed my blood up?
-- No, these do not affect the host DNA or the immune cells.
Q/ Looking at my medical history, is there anything you would suggest testing for with bloodwork?
-- A bone marrow analysis would be essential.
Hope, I answered your query.
Regards,
Dysgammaglobulinemia
Detailed Answer:
Hi,
Thanks for your query.
My answers to your questions are as below.
Q/ Have you ever seen immunization cause multiple illness?
--No, but its possible and very rare.
Q/ What diseases can cause low IgG1 and IgG3 and what medications (see mine below)?
-- Most common cause for such Dysgammaglobulinemia is genetic. Some infections and bone marrow diseases can also cause the same.
Q/ It feels like my immune system is on overdrive and is now burnt out, could something be in my blood that causes this issue, I did have the Antrax vaccine and I am ex military - but you cant test for squalene antibody in this country (Australia).
--Yes, it can happen as you suspect. It is very difficult to identify the culprit.
Q/ I need treatment for Autoimmune Arthritic Diseases and at the same time I need replacement IgG - what drugs would be best for me to treat the arthritis, it seems I need to turn off the immune system and turn it on at the same time?
--This is a difficult scenario. Cell specific immune modulators are the ones you can opt for. These do not inhibit the immune cells in toto but a single group of cells which could be involved in the autoimmune process affecting the joints.
Q/ I had antiretrovirals for 4 weeks - could these have screwed my blood up?
-- No, these do not affect the host DNA or the immune cells.
Q/ Looking at my medical history, is there anything you would suggest testing for with bloodwork?
-- A bone marrow analysis would be essential.
Hope, I answered your query.
Regards,
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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