
Very Low B12 Levels, Taken B12 Shots And Supplements, No Result.Cause?

Thanks for posting your query.
When the B12 therapy is started, for some initial weeks, the body stores are repleted and the serum levels might not show an increase initially. Waiting for 3-4 weeks more might show a considerable improvement.
Serum Homocysteine and Methylmalonic acid levels are considered more reliable indicators of B12 deficiency and its recovery than the concentration of B12 in blood. The levels of these substances are high in B12 deficiency and can be helpful in situations like yours.
Routine monitoring of methylmalonic acid levels in urine is an option for people like you, as a rise in methylmalonic acid levels may be an early indication of deficiency. The decrease in its levels will indicate recovery.
Hope this answers your query.I will be glad to answer the follow up queries that you have.
Wishing you good health.
Regards.

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