Brief Answer:
MDMA in PTSD
Detailed Answer:
Hello
Thanks for the patience,
Due to some personal reasons there was a delay in answering the previous two questions. Looking forward to avoid the same in future.
Use of MDMA is PTSD is a new phenomenon and still mostly in research phase. Two landmark articles stating the same in Journal of psycho pharmacology are :
1) Mithoefer MC, Wagner MT, Mithoefer AT, XXXXXXX L, XXXXXXX SF, Yazar-Klosinski B, Michel Y, Brewerton TD, Doblin R.
Durability of improvement in
post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study.
J Psychopharmacol. 2013 Jan;27(1):28-39. doi: 10.1177/0000. Epub 2012 Nov 20.
2) Mithoefer MC, Wagner MT, Mithoefer AT, XXXXXXX L, Doblin R.
The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study.
J Psychopharmacol. 2011 Apr;25(4):439-52. doi: 10.1177/0000. Epub 2010 Jul 19.
Both these articles have supported the use of MDMA. The benefits are improvement in the PTSD symptoms without memory impairment. However its still not into routine use. The reasons being the controversies:
1) The possibility of abuse .
2) The laws of the state making it difficult to procure
3) Long term benefits are still not evaluated.
4) The studies mentioned are mostly of low sample size.
5) Blinding is difficult in such studies where the interventions are very subjective.
EMDR is one technique which is quite free of controversies and is more effective for PTSD.
As far as my personal experience goes, I have personally never advocated the use of MDMA for psychotherapy.
Looking forward to have more fruitful discussions .....
Regards
Dr. Srikanth Reddy
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