Brief Answer:
please see details
Detailed Answer:
Dear Sir
1. Hazard ratio is simply the risk of occurrence of an event in those with a defined risk factor as compared to the occurrence in those without that risk factor. For example if an event took place in 10 persons out of 100, who were non-smokers in 5 years and hazard ratio for
smoking is 1.6, then the same event will occur in 16 persons out of 100, who will smoke, in next 5 years. This is usually assumed to be independent of other risk factors (multivariate analysis).
2. Yes, one of the catch points of Copenhagen study is that a large proportion of patients in study acquired RBBB through the period of study. Definitely, by logic, those who acquired in later years, had more likelihood of acquired diseases as compared to those where it was purely congenital and not associated with any underlying heart condition. Because those who acquired it over a period of time, may have some associated cause like
COPD,
ischemia, older age or quicker degeneration of conduction system. Yes, as per Copenhagen study, the risk exists even after adjusting for other major cardiovascular risk factors.
3. Yes we do see patients who have RBBB for years and they continue to live without serious health issues.
4. In conclusion, Current literature and logic says, that those with RBBB which is likely to be congenital and do not have symptoms or
structural heart disease, will continue to have no or minimal effect on their health due to this RBBB. Whatever little Bad effect they may have , can not be prevented, by means available at present, as per current knowledge. They however should adopt healthy life style and preventive life style , to prevent future cardiovascular event.
Hope this provides more insight. If I am not clear at any point please feel free to discuss.
Sincerely
Sukhvinder