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What Causes Frequent Vomiting And Acidity After Taking Akt3?

Posted on Mon, 12 Oct 2015

Question: Hello my wife has been diagnosed with TB in her ovary.....the medicine Akt3 is causing lot of nausea frequent vomiting, acidity and uneasiness. She is suffering a lot. Can anyone please help how to get over this

Answered by Dr. Divakara (1 hour later)

Brief Answer:
Need to know since how long she is on AKT3.

Detailed Answer:
Hi

Greetings from Dr Divakara P
Thanks for posting your query.

First of all I need to know since how long she has been on AKT3 medicine.

This is important because if she is on the medicine since few days only then she has to take acidity medications along with AKT3 to control vomiting.

But if she is on AKT3 for few weeks then it means she is not tolerating some component of AKT3 , in that case that component ( AKT3 contains 3 drugs) has to be identified and replaces with alternative drug.

Also there is a possibility of liver damage due to AKT3 . To check for that I recommend a test called Liver function test.

Kindly let me know the details asked .

Regards.

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Divakara (44 minutes later)

Sir thanks for answering ....she is on that drug for month now and few days back she had undergone a jaundice test which also turned out to be negative ....there is lot of weakness which she feels now and she is what i feel under going a phase of depression ....how long will it take for her body to accept these medicines or is it something else that she should do to get over these effeffects

Answered by Dr. Divakara (32 minutes later)

Brief Answer:
May need to replace Rifampicin.

Detailed Answer:
Hi

Thanks for the follow up.

If she is on this medication for one month then it means she is not tolerating one component of AKT3.

AKT3 contains 3 drugs - Rifampicin, Isoniazid and Ethambutol. Among these the probability of intolerance is high for Rifampicin. So she may have to take an alternative for Rifampicin and continue Isoniazid and Ethambutol.

But since Rifampicin is an important component of AKT3 , I recommend her to use acidity medications like Rabeprezole for 1-2 weeks while continuing AKT3.

If inspite of this she continues to vomit then ask your doctor for an alternative for Rifampicin.

Any clarification feel free to ask.

Regards.

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Divakara (20 hours later)

Hello sir
She is already taking pentadoc and emeset for the acidity part , also her liver was weak in the childhood . She has been told to switch to Akt4 now . Is that ok sir and also i hope that she would be able to convince now . Please share your valuable views on these aspects whether switching to Akt4 is ok, effect on her liver and conceive part
Thanks and regards

Answered by Dr. Divakara (26 hours later)

Brief Answer:
AKT4 may aggravate her Vomiting.

Detailed Answer:
HI

Thanks for the informations .

First of all I need to know what is her present Liver condition because if her liver is compromised she will not tolerate either AKT3 or AKT4. So I advise a Liver function test for her . Kindly get it done and revert back with report.

Now AKT4 consists of 4 TB drugs ( AKT3 + Pyrazinamide ) . Actually AKT4 is a proper treatment to begin with than AKT3. But changing over to AKT4 will not resolve her symptoms , infact it may even aggravate nausea or vomiting.

She can switch over to AKT4 but do get Liver function test for her , if it is deranged then she has to be given alternative medications for Rifampicin Component.

Hope this information was useful to you.
Any clarifications feel free to ask.

Regards

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar