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What Do Non-reactive Results After An Elisa Test Indicate?
Question: Hello I had an unprotected oral sex on the night of 3 January 2015. I was the insertive partner nothing else happened
I tested with p24 antigen and antibody CMIA test several times( at 10, 15, 30, 52, 72days) The last test was done on 91 day. All came back mon reactive. Do I still need to test more.Pls Advice.
I tested with p24 antigen and antibody CMIA test several times( at 10, 15, 30, 52, 72days) The last test was done on 91 day. All came back mon reactive. Do I still need to test more.Pls Advice.
Brief Answer:
At 6 months repeat test advised.
Detailed Answer:
Thanks for your query at HCM.
I understand your concern and situation.
I realize that you had got tested for HIV antibodies and antigen on several occasions and each time the results were negative. But still I recommend you to get tested at 6 months for confirmation by ELISA TEST. As it has been reported in few cases where delayed immune response were seen up to six months. But it is 99.99% likely for tests to remain negative. So you don't have to worry. It is just a routine protocol by international guidelines. Follow safe sex practices in future.
Take care.
Hope I answered your query.
If no clarifications then you can close the discussion and rate the answer.
Dr. Sheetal Verma
At 6 months repeat test advised.
Detailed Answer:
Thanks for your query at HCM.
I understand your concern and situation.
I realize that you had got tested for HIV antibodies and antigen on several occasions and each time the results were negative. But still I recommend you to get tested at 6 months for confirmation by ELISA TEST. As it has been reported in few cases where delayed immune response were seen up to six months. But it is 99.99% likely for tests to remain negative. So you don't have to worry. It is just a routine protocol by international guidelines. Follow safe sex practices in future.
Take care.
Hope I answered your query.
If no clarifications then you can close the discussion and rate the answer.
Dr. Sheetal Verma
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
1. Is CMIA test not Elisa.Is CMIA test not accurate. 2. What can be the reasons for delayed immune response. I am not on any kind of drugs but I took Benadryl and strepsils for few days. 3 Can the antigen part of the test be affected by some reasons as I screened for p 24 at various intervals are there any chances that the antigen detection may have been missed. 4 I am really worried , as some say test at 3 month conclusive some say 6 month. 5. for last 2 week I developed cough with sputum is this a symptom
Brief Answer:
99.99% that you will be negative.
Detailed Answer:
Well come back.
1.CMIA test is a chemiluminescent microparticle immunoassay for the simultaneous qualitative detection of human immunodeficiency virus (HIV) p24 antigen and antibodies to HIV type 1 (HIV-1 group M and group O) and/or type 2 (HIV-2) in human serum and plasma (EDTA and heparin) based on chemiluminescent assay. HIV ELISA is based on enzymes and substrates detects antigen,antibodies or both. These both tests are highly reliable(97-99.99%) sensitive.
2. The reason for delay in immune response could be genetic, malignancies, immunocompromized states like transplants, etc.
3. In blood firstly the virus is detected by PCR then antigen appears then antibodies. Till 12 weeks due to low viral load it is possible that antigen goes undetected.
4. Yes it is said between 3-6 months. But better at 6 months to be on the safer side.
5. No cough with sputum cannot be directly linked to HIV it could be seasonal flu with secondary infection. Steam inhalation and antibiotics suggested.
Take care.
99.99% that you will be negative.
Detailed Answer:
Well come back.
1.CMIA test is a chemiluminescent microparticle immunoassay for the simultaneous qualitative detection of human immunodeficiency virus (HIV) p24 antigen and antibodies to HIV type 1 (HIV-1 group M and group O) and/or type 2 (HIV-2) in human serum and plasma (EDTA and heparin) based on chemiluminescent assay. HIV ELISA is based on enzymes and substrates detects antigen,antibodies or both. These both tests are highly reliable(97-99.99%) sensitive.
2. The reason for delay in immune response could be genetic, malignancies, immunocompromized states like transplants, etc.
3. In blood firstly the virus is detected by PCR then antigen appears then antibodies. Till 12 weeks due to low viral load it is possible that antigen goes undetected.
4. Yes it is said between 3-6 months. But better at 6 months to be on the safer side.
5. No cough with sputum cannot be directly linked to HIV it could be seasonal flu with secondary infection. Steam inhalation and antibiotics suggested.
Take care.
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Finally till that what precautions should I take till 6 months are complete with my family. 2 how do I protect my son as we shared same bed are there any chances I have passed the virus to him inadvertently. 3 At various sites I have read that testing with p 24 antigen and hiv1 and 2 antibody is conclusive at 91 days no further testing is required why is it so. They say that viremia peaks around 3- 4 weeks and also 95 % of people will develop antibodies by 1 month rest 5 % can be detected at 3 months.
4 Does oral sex posseses such a high degree of risk. 6 what are my chances of showing up postive . 7 should I test on 5 th July will be sufficient.the incident happened on the night of 3 January 2015
4 Does oral sex posseses such a high degree of risk. 6 what are my chances of showing up postive . 7 should I test on 5 th July will be sufficient.the incident happened on the night of 3 January 2015
Brief Answer:
Practically no chances of HIV.
Detailed Answer:
Hi
1. There is no need for any specific protection other than use of barrier methods during intercourse.
2. Do not give your blood to any relative. Do not touch direct wounds of anyone in family.
3.Yes in majority of cases tests are conclusive at 12 weeks. But as I said there is no harm in getting one more test at 6 months.
4.Yes oral sex also carries a risk. But highest risk is in penetrative sex.
5.Your chances of showing up positive is extremely low (.001%).
6.Yes you can get tested in July on proposed dates.
Take care
Practically no chances of HIV.
Detailed Answer:
Hi
1. There is no need for any specific protection other than use of barrier methods during intercourse.
2. Do not give your blood to any relative. Do not touch direct wounds of anyone in family.
3.Yes in majority of cases tests are conclusive at 12 weeks. But as I said there is no harm in getting one more test at 6 months.
4.Yes oral sex also carries a risk. But highest risk is in penetrative sex.
5.Your chances of showing up positive is extremely low (.001%).
6.Yes you can get tested in July on proposed dates.
Take care
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Above answer was peer-reviewed by :
Dr. Raju A.T
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