What Does A Titre Of 1: 320 Mean With Typhi O And Typhi H?
Thanks for the query.
Typhi O and Typhi H are the two antigens present in the patients infected by salmonella typhi. O stands for somatic and H stands for Flagellar. But presence of these two antigens in specimens from any persons does not invariably denote infection by salmonella. Because the titre of these 2 should be compared with the values of that locality.
In general, a titre value of more than 1:200 dilutions can be taken as a disease condition. So, a titre of 1:320 indicates that you are infected by salmonella typhi bacteria. Therefore I would say that the drug which you were taking was not effective or may be the bacteria is resistant to the drug used. It is the most common complicating factor in this disease.
Hence the first thing which should be done is to change the oral antibiotic to a broad spectrum, more powerful antibiotic (like third generation cephalosporin) immediately. A blood culture should be ordered simultaneously to determine the more sensitive drug.
The process can be done as an outpatient under the care of a competent general physician. However if the fever does not subside even after the above treatment, then you should be admitted in a hospital to start intravenous antibiotics. In this time period for fever you can take paracetamol group of drugs.
Diet should be nutritious. Some fresh fruits should be taken. A multivitamin group of drug should be taken daily.
Discuss with your treating doctor and you start the process (as discussed above) at the earliest
Hope this information suffices. Let me know, if you have any more question.
Regards
Thanks for writing back.
Though he has given many antibiotics, presence of fever indicates a persistent infection.
Continue the drug which is being given now.
If there is oral lesion, consult with your treating doctor for ordering a throat swab culture.
If fever does not subside after completing the present drug, then repeat the blood culture test for presence of any more bacteria.
Regards.