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What Does Low RBC Count With High MCV And MCHC Indicate?

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Posted on Mon, 2 Jun 2014
Question: I recently had some blood work done to check my CBC. my RBC was low and MCV and MHCV were elevated. Should I be concerned?
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Answered by Dr. Sree Gouri SR (53 minutes later)
Brief Answer:
Folic acid deficiency

Detailed Answer:
Hi,
Thanks for the query.
According to your description,
Low RBC count with high MCV and MCHC is indicating macrocytic and hyperchromic anemia.
This can be seen in conditions like:
-Folic acid deficiency
-Alcoholism
-Intake of drugs which act as folic acid antagonists etc.
By estimating the levels of folic acid, cynacobalamin, ferritin and iron in blood, the possible cause of the problem can be identified and treatment can be taken accordingly.
In case of folic acid deficiency, supplementing folic acid can help in normalizing the RBC indices.

Hope I have answered your question. I will be available to answer followup questions. If you are satisfied with the response, please give your review at the end of the discussion.
Take care.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Sree Gouri SR

OBGYN

Practicing since :2006

Answered : 5839 Questions

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What Does Low RBC Count With High MCV And MCHC Indicate?

Brief Answer: Folic acid deficiency Detailed Answer: Hi, Thanks for the query. According to your description, Low RBC count with high MCV and MCHC is indicating macrocytic and hyperchromic anemia. This can be seen in conditions like: -Folic acid deficiency -Alcoholism -Intake of drugs which act as folic acid antagonists etc. By estimating the levels of folic acid, cynacobalamin, ferritin and iron in blood, the possible cause of the problem can be identified and treatment can be taken accordingly. In case of folic acid deficiency, supplementing folic acid can help in normalizing the RBC indices. Hope I have answered your question. I will be available to answer followup questions. If you are satisfied with the response, please give your review at the end of the discussion. Take care.