Question: I would kindly ask an oncologist to consult following matter: Should I look for some more detailed cancer search in my situation or consider myself healthy. I was tested for autoimmune autoantibodies (ANA) and the test came back positive; 1:640 nucleolar 1:320 speckled (lab norm: positive= 1:160+). No specific ENA antibodies. I have no symptoms of any connecive tissue disease or any other, normal capillaroscopy and all other test normal (blood count, ESR, CRP, liver enzymes, brain MRI, chest X-ray, abdomen ultrasound, gastric endoscopy, blood protein electrophoresis, neck, armpit and groin lymph nodes ultrasound), I feel healthy. My mother died of lupus/MCTD complications, her first cousin lives with lupus. I was told by multiple doctors (mostly rheumatologists) not to worry as this ANA result is familial with no clinical importance. Are they right? I am worried mostly of underlying cancer as I read that cancer can bring positive ANA of nucleolar pattern or is the familial explanation more likely?