What Does My Double Marker Test Report Indicate?

Posted on Mon, 22 Aug 2016

Question: I m 26 year old female and I got my double marker reports, Please tell me that my report is normal or not? and is there any risk of down syndrome to my baby according to reports.I m attaching reports with it, please tell me is my reports normal or not?

Answered by Dr. Diptanshu Das (46 minutes later)

Brief Answer:
Not at increased risk.

Detailed Answer:
Thanks for asking on HealthcareMagic.

I have gone through your query as well as the attached report and understand your concerns. The summary of the result indicates that you are not at any increased risk of having a baby with Down's syndrome. Hence you need not worry.

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Diptanshu Das (37 minutes later)

What does it mean in reports?

Double test - 1:152, why is is above cut off

And what is my final Trisomy21 + nt value?

Answered by Dr. Diptanshu Das (4 hours later)

Brief Answer:
Explanation provided

Detailed Answer:
Thanks for writing back.

The reports of three independent tests is combined in order to obtain a cumulative probability. In your case, the combination of two tests (double test) has indicated a relatively higher risk but when the results were combined, the summary is similar to population risk (the risk of having a Down syndrome baby that anyone else in from the population has).

NT means nuchal translucency. A characteristic of Down syndrome (Trisomy 21) is increased nuchal translucency. It is measured using ultrasound scan. In your case it measures 1.3mm (which is not a positive value). The increased risk calculation of the double test occurred because the expected value for this was slightly less (0.95 mm for month on month age).

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Diptanshu Das (1 hour later)

So, what do you think doctor,(my overall reports are normal and my baby is safe from down sydrome?)
What's my trisomy 21+ nt risk?

Answered by Dr. Diptanshu Das (2 hours later)

Brief Answer:
You need not worry.

Detailed Answer:
As per my assessment you need not worry. You should still report to your treating gynecologist/obstetrician who would be able to confirm if you need further testing (like chorionic villus sampling) in order to obtain additional confirmation on the mentioned risk. As I have already explained that there is slight deviation from normal though the sum total is within the safe margin.

Regards

Note: For detailed guidance on genetic screening consult a genetics specialist

Above answer was peer-reviewed by : Dr. Prasad