Brief Answer:
I would recommend as follows:

Detailed Answer:

Hello!

Welcome and thank you for asking on HCM!

Regarding your concern, I would like to explain that, as your renal function tests are abnormally doubled, this may be explained by several health conditions (disorders).

First of all an acute illness, like acute inflammation/infection should be reviewed (pneumonia, gastroenteritis, etc) as they may transiently increase BUN and Creatinine.

After successful treatment of such conditions, renal function returns to normality.

Other disorders, like diabetes and chronic uncontrolled long-standing hypertension may have a devastating effect over entire body blood vessels (and kidney circulation as well) leading to chronic renal failure.

A prompt recognition and treatment of these disorders would prevent further organ damages.

Your fasting blood glucose levels denotes a glucose metabolism disorder (glucose intolerance and even diabetes). For better addressing this issue, glycosylated hemoglobin (HbA1C) test should be checked.

A diet modulation and if necessary anti-diabetics should be started after underlying medical consultation.

Also, an appropriate treatment of your hypertension would stop further deterioration and possibly improve your renal function.

In this regard, I recommend discussing with your prescribing physician about the opportunity of stopping Losartan and substituting with a safer antihypertensive class alternative, such as calcium channel blockers (Amlodipine, Lercanidipine, etc). These latter do not interfere and deteriorate renal function.

For better addressing your actual kidney dysfunction, I recommend discussing with your doctor (internist, GP or nephrologist) for some additional testing, like:

- complete blood count (anemia is frequently present in chronic renal failure),
-complete urine test,
- creatinine clearance,
- microalbuminuria,
- uric acid,
- acid-base status coupled with blood electrolyte levels (arterial blood gas tes),
- HbA1C,
- blood proteins level,
- blood lipid profile,
- PCR,
- ANA, XXXXXXX etc (auto-antibodies if suspicions of autoimmune disorders), etc.

Remember that a better thyroid function balance, would yield a better BP control and hence a better renal function status.

I recommend also to check thyroid function test.

A full review of the above mentioned tests, would be valuable in properly addressing your concern.

Hope to have been helpful to you!

Feel free to ask me in case of further uncertainties!

Kind regards,

Dr. Iliri

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