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What Does This Blood Report Indicate?
Question: I am 18 week pregnant and I am having e trait my husband Hb typing report suggest like dis
Hb F 0.0%
Hb A2 33.8%
Hb A 62.2%
Interpretation: suggestive of Hb E.Trait
Is he also having e trait n is it going to cause any problem to our baby?
Hb F 0.0%
Hb A2 33.8%
Hb A 62.2%
Interpretation: suggestive of Hb E.Trait
Is he also having e trait n is it going to cause any problem to our baby?
Brief Answer:
The child may be HB-E homozygous.
Detailed Answer:
Hello,
Thanks for the query to hcm,
as both of you are heterozygous for Hb-E trait, there are 50 per cent chances that the child may be HB-E homozygous or Hb-e HETEROZYGOUS. The trait is not going to create any trouble regarding pregnancy at all as it will be managed as any normal pregnancy.
However you must know that:-
1.Hemoglobin E disease results when the offspring inherits the gene for HbE from both parents. At birth, babies homozygous for the hemoglobin E allele do not present symptoms due to HbF (fetal hemoglobin) they still have. In the first months of life, fetal hemoglobin disappears and the amount of hemoglobin E increases, so the subjects start to have a mild β-thalassemia. People who are heterozygote for hemoglobin E (one normal allele and one abnormal allele) do not show any symptoms (there is usually no anemia or hemolysis). Subjects homozygous for the hemoglobin E allele (two abnormal alleles) have a mild hemolytic anemia and mild enlargement of the spleen.
As far as you both are concerned with Hb-E trait, you must understand that people who have hemoglobin E trait (heterozygous) are asymptomatic and their state does not usually result in health problems. They may have a low mean corpuscular volume (MCV) and very abnormal red blood cells (target cells). Its clinical relevance is exclusively due to the potential for transmitting E or β-thalassemia.
I hope i have answered your query in detail,
Regards
The child may be HB-E homozygous.
Detailed Answer:
Hello,
Thanks for the query to hcm,
as both of you are heterozygous for Hb-E trait, there are 50 per cent chances that the child may be HB-E homozygous or Hb-e HETEROZYGOUS. The trait is not going to create any trouble regarding pregnancy at all as it will be managed as any normal pregnancy.
However you must know that:-
1.Hemoglobin E disease results when the offspring inherits the gene for HbE from both parents. At birth, babies homozygous for the hemoglobin E allele do not present symptoms due to HbF (fetal hemoglobin) they still have. In the first months of life, fetal hemoglobin disappears and the amount of hemoglobin E increases, so the subjects start to have a mild β-thalassemia. People who are heterozygote for hemoglobin E (one normal allele and one abnormal allele) do not show any symptoms (there is usually no anemia or hemolysis). Subjects homozygous for the hemoglobin E allele (two abnormal alleles) have a mild hemolytic anemia and mild enlargement of the spleen.
As far as you both are concerned with Hb-E trait, you must understand that people who have hemoglobin E trait (heterozygous) are asymptomatic and their state does not usually result in health problems. They may have a low mean corpuscular volume (MCV) and very abnormal red blood cells (target cells). Its clinical relevance is exclusively due to the potential for transmitting E or β-thalassemia.
I hope i have answered your query in detail,
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
What are the chances dat my child is going to carry e disease or thalamessia?
Brief Answer:
answered
Detailed Answer:
Hello,
The chances that he would be a HB-e DISEASE is 75 % and 25% that he would be normal. Of the 75% , 50 % chance is that he could be Hb-E heterozygous and 25% chance that he may be HB-E homozygous and may have thalasemia.
Regards
answered
Detailed Answer:
Hello,
The chances that he would be a HB-e DISEASE is 75 % and 25% that he would be normal. Of the 75% , 50 % chance is that he could be Hb-E heterozygous and 25% chance that he may be HB-E homozygous and may have thalasemia.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Is it worrisome? Is my child ever going to ve normal life?n hw to check if he is carrying dis disease or not?
Brief Answer:
answered
Detailed Answer:
Hello,
You would have to wait for the delivery to check for his blood group and him being HbE disease , through a Hb-electrophoresis method.
In all cases the child would be able to lead a normal life even as a trait heterozygous where most children are asymptomatic . Only in homozygous cases, that he may develop beta-thalassemia but always of a mild variety which should not affect his life.
Regards
answered
Detailed Answer:
Hello,
You would have to wait for the delivery to check for his blood group and him being HbE disease , through a Hb-electrophoresis method.
In all cases the child would be able to lead a normal life even as a trait heterozygous where most children are asymptomatic . Only in homozygous cases, that he may develop beta-thalassemia but always of a mild variety which should not affect his life.
Regards
Note: For detailed guidance on genetic screening consult a genetics specialist
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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