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What Is R1 Dilation Regarding Secondary Syphilis?

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Posted on Sat, 21 Jun 2014
Question: My maid detected with secondary syphilis. Undergone 10 days monocef 1 gm iv and 14 days minoz.tpha was 1:640. After year tested positive for vdrl at R1 solution and tpha 1:160. Doctors asking to take peniciline for seronegative, but assuring that he is cured. Kindly give your veiw. What is r1 dilition
, tpha value showing improvement and he is fully cured or not
doctor
Answered by Dr. Praveen Rodrigues (31 minutes later)
Brief Answer:
Seronegativity not an indicator; azithromycin best

Detailed Answer:
Hi there XXXXXX.
I understand your concerns & empathise.
Your maid is in the clear & no further tests or treatment required.
Seronegativity is often never achieved & if there is a 2-4 fold drop in titre (as it is in your case), you may consider the treatment as being effective.
R1 dilution is a difficult concept to understand & involves an entitiy called a 'prozone phenomenon' that occurs in these serology reactions' ...do not sweat over this..it suffices that it was done & the lab appears competent.
As I said, no further treatment is required but for peace of mind, please do take a 15 day course of Azithromycin 1 gram tab taken twice/day for 15 days & close the chapter. Remember to impress upon him the virtues of safe sex & do hope his partner/s have been treated to prevent recurrences.
Good Luck & trust all your queries have been suitably addressed & he does appear well on the road to recovery if not totally cured. Cheers.
Dr Praveen Rodrigues MD

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Praveen Rodrigues (10 minutes later)
Thnx doc.....This was valuable and very helpful information. I will educate him for the above matter so that no further suffering to others happens.
doctor
Answered by Dr. Praveen Rodrigues (1 minute later)
Brief Answer:
Cheers

Detailed Answer:
Good Luck & Wish you all the best. It appears you are a good employer & a humane, rationale & considerate person.
Best wishes.
Dr Praveen Rodrigues MD
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Praveen Rodrigues

Dermatologist

Practicing since :1993

Answered : 1193 Questions

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What Is R1 Dilation Regarding Secondary Syphilis?

Brief Answer: Seronegativity not an indicator; azithromycin best Detailed Answer: Hi there XXXXXX. I understand your concerns & empathise. Your maid is in the clear & no further tests or treatment required. Seronegativity is often never achieved & if there is a 2-4 fold drop in titre (as it is in your case), you may consider the treatment as being effective. R1 dilution is a difficult concept to understand & involves an entitiy called a 'prozone phenomenon' that occurs in these serology reactions' ...do not sweat over this..it suffices that it was done & the lab appears competent. As I said, no further treatment is required but for peace of mind, please do take a 15 day course of Azithromycin 1 gram tab taken twice/day for 15 days & close the chapter. Remember to impress upon him the virtues of safe sex & do hope his partner/s have been treated to prevent recurrences. Good Luck & trust all your queries have been suitably addressed & he does appear well on the road to recovery if not totally cured. Cheers. Dr Praveen Rodrigues MD