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What Is The Appropriate Treatment For Homozygus For Factor V Leiden?
Question: What is the most appropriate treatment for one who is homozygus for Factor v Leiden and not had any clots. Also knowing I am double positive my kids for sure have one copy (husband negative). Are contact sports like football still ok or are teens advised not to play these types of sports. If they play, could a teen take aspirin during sports seasons? I have seen a specialist once but I have since seen contradictions everywhere I read. Is there a test for my kids and i to see how susceptable we ar to blood clots?,
Hello and thank you for sending your question.
Your question is a very good one and I will work on providing you with some information and recommendations.
As you know mutations affecting Factor V Can lead to significant increases in susceptibility to blood clots. Patients who are heterozygous for this Have a 5 to 7 fold increased risk for developing a thrombosis compared to the average population.
In patients who are homozygous this risk increases to at least 25 to 50 fold.
At this time there are no indications to start prophylactic anticoagulation for patients who harbor the factor five leiden mutation whether it be heterozygous or homozygous.
You are correct in assuming that your children will inherit one copy of the factor five mutation. There is no indication for them to limit physical activity if they inherit this mutation. Also there is no indication to take anything such as aspirin to prevent blood clots.
Several things are important to remember especially in the case of homozygous for this mutation. There are certain risk factors which certainly elevate risk for developing thrombosis even higher. This occurs in cases of obesity, immobility, hospitalization, surgery or trauma, pregnancy, taking hormonal medications such as contraceptives, Prolonged air travel or car travel Or the development of some type of Autoimmune conditions as well.
In your case it is very important to be attentive to these risk factors which I mentioned above. I think it would also be reasonable for you to establish care with a hematologist for Consultation and surveillance.
Thanks again for sending your question. Please let me know if you have any additional specific concerns.
Dr Galamaga
Your question is a very good one and I will work on providing you with some information and recommendations.
As you know mutations affecting Factor V Can lead to significant increases in susceptibility to blood clots. Patients who are heterozygous for this Have a 5 to 7 fold increased risk for developing a thrombosis compared to the average population.
In patients who are homozygous this risk increases to at least 25 to 50 fold.
At this time there are no indications to start prophylactic anticoagulation for patients who harbor the factor five leiden mutation whether it be heterozygous or homozygous.
You are correct in assuming that your children will inherit one copy of the factor five mutation. There is no indication for them to limit physical activity if they inherit this mutation. Also there is no indication to take anything such as aspirin to prevent blood clots.
Several things are important to remember especially in the case of homozygous for this mutation. There are certain risk factors which certainly elevate risk for developing thrombosis even higher. This occurs in cases of obesity, immobility, hospitalization, surgery or trauma, pregnancy, taking hormonal medications such as contraceptives, Prolonged air travel or car travel Or the development of some type of Autoimmune conditions as well.
In your case it is very important to be attentive to these risk factors which I mentioned above. I think it would also be reasonable for you to establish care with a hematologist for Consultation and surveillance.
Thanks again for sending your question. Please let me know if you have any additional specific concerns.
Dr Galamaga
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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