Brief Answer: Dose adjustment through studies. Detailed Answer: Hi, thanks for using HCM. I went through your query and understood your concerns. Dose of each medication for adults is found out using studies. In a study they will concentrate on dose of medication which is effective with minimal side effect on a large population ( containing different age, weight) . Dose of particular drug depends on many factors in body like weight, fluid composition, lean body mass etc. Only for few medications with narrow therapeutic range means only at particular dose they cause full effect slight increase or decrease causes no effect or side effects, in these medications we usually prescribe based on body weight. prolia medication has broad range of theraputic index. means active at wide range of concentration and less side effects , so its dise is fixed as 60 mg for adults. Hope I answered your query. Feel free to ask further related query. I will be glade to answer them. Wish you a good health . Regards

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