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When Can Remeron Be Started While On Lexapro?

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Posted on Tue, 14 Jun 2016
Question: Let me start by saying I am super sensitive to medication. I was put on 2.5 mg of lexapro. I am also on 7.5 mg of remeron and 200mg of Wellbutrin SR twice a day along with 6 mg of ativan which I am planning on tapering off of after I am stabilized
I ended up in the ER Wed. after my second dose of Lexapro on Tues. night with Serotonin syndrome. I have never had suicidal thoughts and agitation that was horrible. When can I safely start the new dose of remeron? My doctor is on vacation and his colleague will not make any med decisions since he has never seen me and I cant get in until next week. My
depression is breaking through again.

My original doc wanted to up the remeron before he left to 15mg since Ive had good signs with it, but I am afraid the lexapro is still in my system and will react with remeron again.
doctor
Answered by Dr. Dr. Chintan Solanki (1 hour later)
Brief Answer:
after 4 dyas of last dose of lexapro, 7.5 mg is starting dose

Detailed Answer:
Hello,

Thanks for writing to us back.

Half life of lexapro is around 32 hours. It is cleared from the body maximum in 4 days after its last dose. After that you can restart your remeron. Starting dose should be 7.5 mg.
Hope I have answered your query, I will be happy to help further.

Regards,

Dr.Chintan Solanki.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Chintan Solanki (2 hours later)
Hello, So, there would be a reaction between the remaining lexapro in my body and remeron if I took it now? Also, I was taking 7.5mg of remeron for sleep, what is the therapeutic dose for Major Depressive Disorder?
doctor
Answered by Dr. Dr. Chintan Solanki (11 hours later)
Brief Answer:
no reaction likely

Detailed Answer:
Hi,

Thanks for follow up and sorry for delayed response due to some unavoidable work.

You have entered in 3rd day already from last dose of lexapro. There should be no reaction if you take remeron now as there is negligible amount of lexapro is there in your body now.

In general therapeutic dose of remeron for Major Depressive Disorder is 15 mg, it can be increased up to 30 mg when needed.

Feel free to discuss further.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Chintan Solanki (2 hours later)
i have been off remeron for one night and I actuality feel pretty good! Why is this? All I have taken is my Wellbutrin 200 SR which I have been taking for 18 years (doc said it pooped out and I will have to taper off of it, still keeps me from smoking though!) and 2mg of ativan? Could the remeron have been causing / exacebating my MDD and GAD in a smaller serotonin syndrome? Also, what do you think of the AD Serzone if they decide to put me on another one? I wish I could feel like this all the time! Thank you you hsve no idea how much this will change many lives if I can get back to a somewhat normal state. We get the same old run around here in the states, throw a benzo at the problem...
doctor
Answered by Dr. Dr. Chintan Solanki (10 hours later)
Brief Answer:
No, remeron cannot worsen MDD or GAD

Detailed Answer:
Hi,

Again sorry for delayed response.

Remeron cause some sedation. It may be possible that when you skipped the dose for one night , there is no drowsiness on the next day and you felt alert and relax.

Remeron cannot exacerbate MDD or GAD.

I never recommend Serzone due to its side effect profile and in many countries it is not used now.

If you are in search for other option I recommend trying imipramine (tofranil).

You can ask your doctor for the same.

If still any query there, I will be happy to answer. If not, you can close the discussion and give your feedback and rating so I can improve my service.

In future if you wish you can contact me directly with following link:
http://bit.ly/drchintansolanki

by clicking on 'Ask me a question' on same page with three follow up questions.

All the best and take care.
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Dr. Chintan Solanki

Psychiatrist

Practicing since :2007

Answered : 2407 Questions

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When Can Remeron Be Started While On Lexapro?

Brief Answer: after 4 dyas of last dose of lexapro, 7.5 mg is starting dose Detailed Answer: Hello, Thanks for writing to us back. Half life of lexapro is around 32 hours. It is cleared from the body maximum in 4 days after its last dose. After that you can restart your remeron. Starting dose should be 7.5 mg. Hope I have answered your query, I will be happy to help further. Regards, Dr.Chintan Solanki.