Would Benadryl Cause Peyronie's Disease After Long Term Use?

Posted on Tue, 24 Apr 2018

Question: I have been taking Benadryl every night for years and just read where it could be a cause for my Pyronnies problems. What’s your opinion .

Answered by Dr. Panagiotis Zografakis (42 minutes later)

Brief Answer:
no...

Detailed Answer:
Hello,

diphenhydramine (benadryl) does not seem to be connected in any way with Peyronie's disease. I've never ever heard or read anything about it. Peyronie's disease is a little enigmatic in etiology. It occurs more commonly in people who:
-smoke
-have diabetes
-are older
-have lipid disorders
-have vitamin E deficiency
-have Dupuytren's contracture

Injuries may also cause this disease.

Benadryl may make erectile dysfunction worse in some patients.

I hope you find my comments helpful!
Kind Regards!

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar