Hello Good Evening, As you have issue of missed period frequently, which is due to some common reason like: -Pregnancy -Menopause -Stress and anxiety -Excessive weight loss, or weight gain -Hormonal imbalance -Hypothyroidism -PCOS You are looking suffered from PCOS. PCOS (Polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female sub-fertility and the most frequent endocrine problem in women of reproductive age. The principal features are anovulation, resulting in irregular menstruation, amenorrhoea, ovulation-related infertility, and polycystic ovaries; excessive amounts or effects of androgenic (masculinizing) hormones, resulting in acne and hirsutism; and insulin resistance, often associated with obesity, Type 2 diabetes, and high cholesterol levels. You are Spironolactone, which is a diuretic, which gets rid of excess salt and water in the body. It also reduces androgen levels in women with polycystic ovary syndrome (PCOS). Spironolactone used alone can cause irregular bleeding and could cause problems if used during pregnancy. For these reasons, it is usually taken along with birth control pills. It is used to control irregular menstrual bleeding and to reduce hirsutism. Side effects from spironolactone may include: -Irregular menstrual periods, with higher doses of the medicine. -Rash. -Scalp hair loss. -Nausea or fatigue, with higher doses of the medicine. -Cramping, diarrhea. -Drowsiness, lack of energy. -Headache, confusion. Regards, Dr. Naresh Jain.