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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Adenomyosis And Endometrioses With Enlarged Uterus. Advised Operation. Using GnRH Agonist Before Operation Recommended?

Hello doctor,
I am Asian. I got adenomyosis and endometriose for 4 years. I was operated 6 years ago for the first baby. Until now I have not treated yet. It grows quickly, I have enlarged uterus (150x 100x75mm). They adviced me to operate it as soon as possile. I want to ask you should I use GnRH agonist before opeartion? How long do I use it. Compare Zoladex vs Enantone? which one is better? Thank you so much
Thank you
Wed, 10 Jul 2013
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General & Family Physician,  's  Response
Hello,

Thanks for posting HCM,

I believe that if your doctor(s) have suggested immediate operation, it means there would not be immediate use for treatment of your endometriosis with GnRH agonist. You could be placed with a gonadotropin such as zoladex or enatone after the surgery so as to treat the remaining tissues that were not excised.
Zoladex and enantone are the same class of drugs known as GnRh agonist or gonadotrophins and there may be slight difference in their pharmocology but the treatment benefits for each will likely depend on the patient. Both can work perfectly well for a single patient and for the other, one might be better. So, it will depend on your treating doctors (probably gynobs) to decide on which he prefers dealing with.

Hope this helps and wish you the best
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Adenomyosis And Endometrioses With Enlarged Uterus. Advised Operation. Using GnRH Agonist Before Operation Recommended?

Hello, Thanks for posting HCM, I believe that if your doctor(s) have suggested immediate operation, it means there would not be immediate use for treatment of your endometriosis with GnRH agonist. You could be placed with a gonadotropin such as zoladex or enatone after the surgery so as to treat the remaining tissues that were not excised. Zoladex and enantone are the same class of drugs known as GnRh agonist or gonadotrophins and there may be slight difference in their pharmocology but the treatment benefits for each will likely depend on the patient. Both can work perfectly well for a single patient and for the other, one might be better. So, it will depend on your treating doctors (probably gynobs) to decide on which he prefers dealing with. Hope this helps and wish you the best