Hi, Cerefolin is a prescription medication that contains a combination of active ingredients including L-methyl folate, pyridoxal 5 -phosphate, and methylcobalamin. These active ingredients are effective in providing the necessary vitamins and nutrients needed for individuals with MTHFR genetic mutations. MTHFR mutations can interfere with the body s ability to process folate, which can lead to a deficiency in this essential nutrient. This can increase the risk of certain health problems, including cardiovascular disease, stroke, and certain types of cancer. Supplementation with L-methyl folate, which is the active form of folate, can help to overcome this deficiency and promote better health outcomes. Pyridoxal 5 -phosphate and methylcobalamin are also important in supporting healthy methylation processes in the body. It is important to note that not all individuals with MTHFR mutations require supplementation with L-methyl folate or other active ingredients. The severity and specific type of mutation can vary between individuals and may not necessarily lead to a folate deficiency. It is recommended that you discuss the use of Cerefolin with your healthcare provider, who can provide more information about the potential benefits and risks of this medication based on your health status and specific MTHFR mutation. They can also recommend alternative treatments if necessary, given your allergy to sulfa medications. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician