Hi, Glycomet contains metformin which is a diabetes drug. It is used in women diagnosed with polycystic ovarian syndrome. It is believed to work by improving insulin sensitivity which commonly associated with PCOS. In PCOS there is an element of insulin resistance which interferes in conceiving. By lowering the insulin level, Glycomet allows many women to cycle more normally. Glycomet improves menstrual cycle regularity and lower body mass index (BMI), testosterone, luteinizing hormone within 6 months of treatment in women with PCOS who are normal weight or overweight. It is a very safe and first line treatment for PCOS. In PCOS, irregular periods are going to be there. By using Regestrone, you can regularise them. Regestrone contains norethisterone which is used to treat various menstrual problems. Issues including painful, heavy or irregular periods, premenstrual syndrome and a condition called endometriosis. It is man made version of the natural female sex hormone progesterone and PCOS is a disease where there is hormonal imbalance. So, Regestrone is a safe and effective option for PCOS. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Zubayer Alam, General And Family Physician