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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Are High Levels Of Cortisol Related To Adrenal Glands?

Hello, I am 34 and I would like to ask you if higher cortisol level and higher progesterone level can be sign of some medical problem - maybe connected with adrenal glands? In the morning my blood cortisol was ok - 558,5 nmol/L, but in the evening it was high - 670,1 nmol/L, while ACTH was ok. Cortisol during ACTH test was also ok before infusion - 352,2 nmol/L and high after infusion - 588,1 nmol/L. My progesterone was higher - 100,7 nmol/L - and I am not pregnant. All thyroid hormons are all right. My health problems includes higher blood pulse (heart pressure is ok), chronical fatigue (I sleep a lot), shortness of breath during little walk, frequent urination and occassional blood and slime in urine (all bacterial tests of urinal tract are negative), reduced bleeding during menstruation with a lot of slime. Should I check other hormons to exclude hormonal problems? Thank You. Alex
Fri, 31 May 2019
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Endocrinologist 's  Response
Hello,

For the high levels of cortisol, you need a dexamethasone suppression test not stimulation with synacthen.

If cortisol is under 50 after dexamethasone, overproduction of cortisol from adrenal glands is ruled out.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Mirjeta Guni, Endocrinologist
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Are High Levels Of Cortisol Related To Adrenal Glands?

Hello, For the high levels of cortisol, you need a dexamethasone suppression test not stimulation with synacthen. If cortisol is under 50 after dexamethasone, overproduction of cortisol from adrenal glands is ruled out. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mirjeta Guni, Endocrinologist