Hi, Seretide (fluticasone/salmeterol) inhaler is a combination medication used to treat asthma and chronic obstructive pulmonary disease (COPD). The medication works by reducing inflammation and widening the airways to make breathing easier. Long-term use of the Seretide inhaler can have some side effects, although these are generally rare and depend on the individual. Some potential side effects include: - Thrush or oral candidiasis: Long-term use of a Seretide inhaler can cause an overgrowth of yeast in the mouth, leading to white patches and soreness. This can be prevented by rinsing the mouth with water after using the inhaler. - Reduced bone density: In rare cases, long-term use of Seretide inhalers may lead to a reduction in bone density, which can increase the risk of osteoporosis and fractures. This is more likely to occur in people who are taking high doses of the medication. - Cataracts and glaucoma: There have been reports of cataracts and glaucoma in people who use inhaled corticosteroids for a long time. However, this is very rare and only occurs at high doses. - Adrenal suppression: In rare cases, long-term use of inhaled corticosteroids like fluticasone can suppress the adrenal gland, which can lead to problems like fatigue, weakness, and weight loss. It s important to note that the benefits of using a Seretide inhaler usually outweigh the risks of side effects, especially if it s the only medication that works for your asthma. If you re considering stopping the medication, you should speak to your doctor first to make sure it s safe and to discuss alternative treatment options if necessary. Abruptly stopping the Seretide inhaler can cause your asthma symptoms to worsen, so it s important to gradually reduce your dose under medical supervision. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician