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Blood Work Indicates Anemia, Smudge Cell, Suspect CLL. Can It Be Due To G6pd?
My blood work indicates anemia and smudge cell which made my doctor suspicion of CLL. I did test for flow cytometry and it was clear. I googled and searched for other possible causes of anemia and smudge cells and main culprit seems to be g6pd. My doctor is reluctant to accept this notion and wants to reconfirm cll by another flow cytometry. Any suggestions?
Mon, 30 Sep 2013
User's Response
HI
Thank for asking to HCM
The G6PD. in it self does be cause of any clinical condition if ever occurs in later life, the only precautions has to be taken in case of G6PD is certain drugs that should be given with great care ( Antimalarial ) otherwise The CLL and G6PD may not be related, until and unless proved, Take care. have good day.
Thank for asking to HCM
The G6PD. in it self does be cause of any clinical condition if ever occurs in later life, the only precautions has to be taken in case of G6PD is certain drugs that should be given with great care ( Antimalarial ) otherwise The CLL and G6PD may not be related, until and unless proved, Take care. have good day.
I find this answer helpful
Hello,
Welcome to Healthcaremagic.
I had gone through your query and understand your concern.
First i have to what is smudge cells and the other possible causes.
Smudge cells are actually lymphocytes.
They're artifacts produced by the rupture of fragile cells during the process of the blood smear preparation.
They're associated with both malignant and reactive lymphocytosis, but a high number is more often seen in chronic lymphocytic leukemia.
They're also common in infectious mononucleosis, pertussis and lymphomas involving peripheral blood. They're rarely encountered in the normal blood smear.
Thus number of smudge cells per 100 lymphocytes is also important in CLL.
To confirm the CLL, the following features shoulb be considered.
1. Lymphocytosis must persist for longer than 3 months.
2. Peripheral blood flow cytometry is the most valuable test to confirm a diagnosis of chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL).
3. Ultrasound abdomen may show splenomegaly.
4. Lymph node biopsy may be necessary to confirm the diagnosis.
Your Flow cytometry results are negative.
Thus consider the other possible causes for smudge cells ( Infectious mononucleosis and other lymphomas )
How ever smudge may also present in normal blood smear.
Finally if nothing is found in investigation, consider lymph node and bone marrow biopsy examination.
Hope this helps.
Please reply for further queries.
Wishing you good health.
Welcome to Healthcaremagic.
I had gone through your query and understand your concern.
First i have to what is smudge cells and the other possible causes.
Smudge cells are actually lymphocytes.
They're artifacts produced by the rupture of fragile cells during the process of the blood smear preparation.
They're associated with both malignant and reactive lymphocytosis, but a high number is more often seen in chronic lymphocytic leukemia.
They're also common in infectious mononucleosis, pertussis and lymphomas involving peripheral blood. They're rarely encountered in the normal blood smear.
Thus number of smudge cells per 100 lymphocytes is also important in CLL.
To confirm the CLL, the following features shoulb be considered.
1. Lymphocytosis must persist for longer than 3 months.
2. Peripheral blood flow cytometry is the most valuable test to confirm a diagnosis of chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL).
3. Ultrasound abdomen may show splenomegaly.
4. Lymph node biopsy may be necessary to confirm the diagnosis.
Your Flow cytometry results are negative.
Thus consider the other possible causes for smudge cells ( Infectious mononucleosis and other lymphomas )
How ever smudge may also present in normal blood smear.
Finally if nothing is found in investigation, consider lymph node and bone marrow biopsy examination.
Hope this helps.
Please reply for further queries.
Wishing you good health.
I find this answer helpful
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