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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Bone Marrow Biopsy Done And MDS Not Progressed, Requiring Blood Transfusion Since February. Taking Multivitamin Is Dangerous?

my husband has MDS, and has had it since 2006, last month he had another bone marrow biopsy and the MDS has not progressed, it is the same as in 06, but now he is needing blood transfusions like once a month since February,
the Oncologist tells us nothing can be done, or given to him, he is 70 yrs old. Also said we need to be careful of to much iron in his blood. that is our concern. He takes a multivitamin daily, is that bad, and how do we know he's had to much iron?

Wed, 14 Aug 2013
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Dentist 's  Response
mds is mylodyplastic syndrome in this case some chromosomal mutation occurs in the blast cell of bone marrow resulting anemia pancytopenia .so quality of patient life decreases due to weakness (anemia) bleeding dis order and due to infection.
blood transfusion is the conventional mode of treatment to counter act the symptoms .but iron over iron over load is the biggest problem with blood transfusion.
to monitor iron overload following parameter is to be measured on frequently
total serum ferritin level...our goal is to keep ferritin level below 1000mcg/l of blood.
another tool is total iron binding protein level.
and also monitor the function of liver ,heart and endocrine to exclude any toxicity of iron over load
for for tunately we hav good chelating agent like deferoxamine (iv),deferasirox(oral) ,deferiprone (oral) to combat angainst iron over load.
u are taking multivitamin ,but in many cases multivitamin contains many minerals incl iron so be sure that the vitamins which is given is free from iron.
now there are many adv therapy like erythropoitin therapy , steam cell transplantation therapy has been evolved with less chance for iron overload
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Bone Marrow Biopsy Done And MDS Not Progressed, Requiring Blood Transfusion Since February. Taking Multivitamin Is Dangerous?

mds is mylodyplastic syndrome in this case some chromosomal mutation occurs in the blast cell of bone marrow resulting anemia pancytopenia .so quality of patient life decreases due to weakness (anemia) bleeding dis order and due to infection. blood transfusion is the conventional mode of treatment to counter act the symptoms .but iron over iron over load is the biggest problem with blood transfusion. to monitor iron overload following parameter is to be measured on frequently total serum ferritin level...our goal is to keep ferritin level below 1000mcg/l of blood. another tool is total iron binding protein level. and also monitor the function of liver ,heart and endocrine to exclude any toxicity of iron over load for for tunately we hav good chelating agent like deferoxamine (iv),deferasirox(oral) ,deferiprone (oral) to combat angainst iron over load. u are taking multivitamin ,but in many cases multivitamin contains many minerals incl iron so be sure that the vitamins which is given is free from iron. now there are many adv therapy like erythropoitin therapy , steam cell transplantation therapy has been evolved with less chance for iron overload