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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Ambien Be Taken While On Oxycodone?

Hi, I am taking oxycodone to manage my pain that I am experiencing from my surgery. I have sleep apnea and use a CPAP machine. I sometimes have difficulty falling asleep at night. Is it safe for me to take either Ambien or diphenylhydramine (such as Advil PM) with the prescribed oxycodone?
Thu, 2 Aug 2018
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General Surgeon 's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

You can take Ambien or Diphenhydramine while you are on Oxycodone. They won’t interact with each other or affect the efficacy of each other. Keep in mind that you feel excessive sleepiness while combining Oxycodone and Diphenhydramine.

Wishing you good health.

Thanks.
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Can Ambien Be Taken While On Oxycodone?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. You can take Ambien or Diphenhydramine while you are on Oxycodone. They won’t interact with each other or affect the efficacy of each other. Keep in mind that you feel excessive sleepiness while combining Oxycodone and Diphenhydramine. Wishing you good health. Thanks.