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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Effexor And Zoloft Be Taken Together?

My psychiatrist changed my meds from Wellbutrin 150mg x1 per day along with Zoloft 150mg x1 per day to Effexor 75mg x1 per day along with the Zoloft 150mg per day. I ve read that the Effexor may add to the serotonin levels. What dosage of the Zoloft would you suggest taking with the Effexor? Thanks in advance. Michelle
Sat, 21 Apr 2018
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General & Family Physician,  's  Response
Hello,

It's not safe to take these medicines together.

Taking Zoloft along with Effexor can increase the risk of a serious condition called the 'serotonin syndrome' which is characterized by confusion, seizure, hallucination, increased blood pressure/heart rate, fever, excessive sweating, blurred vision, muscle stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

In its severe form, it may result in coma and even death. Your treating doctor will reduce the dose of Zoloft or may prescribe an alternate effective medicine to depression.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Mohammed Taher Ali
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Can Effexor And Zoloft Be Taken Together?

Hello, It s not safe to take these medicines together. Taking Zoloft along with Effexor can increase the risk of a serious condition called the serotonin syndrome which is characterized by confusion, seizure, hallucination, increased blood pressure/heart rate, fever, excessive sweating, blurred vision, muscle stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. In its severe form, it may result in coma and even death. Your treating doctor will reduce the dose of Zoloft or may prescribe an alternate effective medicine to depression. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali