Hi, I m a retired RN and my husband has recently started taking cymbalta 30mgs qd, plaquenil 200mg qd. He is also on coumadin 2mg qd for hx of DVT and PE. the side efeects from the cymbalta are HORRENDOUS and trying to withdraw from it is worse than HORRENDOUS. Please explain how MD s just arbitrarily give out meds with not one single thought of what a patient has to go through in the event they need to DC the meds. it s unethical!!.. sorry, perhaps i m just venting. there is MUCH more to the story. We are seeing the rhuematologist tomorrow after she tried to cancel the appointment and put him on ENBREL and then see him in a few weeks!!! i lost my temper and now an appointment cancellation suddenly popped up out of nowhere and she will now see us. I hope to continue this conversation tomorrow after we see what she has to offer and explain. I refuse to let him begin Enbrel for moderate to severe OA. He s young only 62!..NEVERMIND!! I m not paying..sorry