I strongly recommend not to skip the medication but you can have a grapefruit along with it once in a while. Here the fact about grapefruit & Simvastatin: Grapefruit contains a chemical that interferes with your body’s ability to break down or metabolize certain statin medications. When statin takers ingest LARGE amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects. Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. Side effects from grapefruit-statin interaction can be mild, such as muscle and joint pain. Severe side effects include muscle fiber breakdown and kidney failure. There are several studies about grapefruit and statin interaction, and recent ones suggest that moderate grapefruit consumption can be compatible with taking lovastatin and other statin drugs ‘Go ahead and eat the grapefruit once in a while– but do not skip your medication. HOPE THIS HELPS RELIEVE YOUR ANXIETY. DR SAHSI.