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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can N-Acetylcysteine And Nattokinase Be Taken For Idiopathic Pulmonary Fibrosis?

I have IPF and am two years into it. I am currently on OFEV which appears to have helped a little but breathing appears to be degrading in the last few weeks. I am interested in the advantages of Nattokinase and N - ACETYL CYSTEINE and if some claims of fibrosis reduction is possible? I am 75 years old and in otherwise good health.
Thu, 24 Jan 2019
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General & Family Physician 's  Response
Hi,

Nattokinase is an enzyme extracted and purified from a Japanese food called nattō, which is made from fermented soybeans. It exhibits a strong fibrinolytic activity. It "thins the blood" and helps break up blood clots.

It intake is possibly effective for high blood pressure as some research suggests that taking nattokinase daily for up to 8 weeks can reduce blood pressure in people with hypertension.

N-acetylcysteine is a medication used to loosen thick mucus in individuals with cystic fibrosis or with chronic obstructive pulmonary disease.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, interstitial lung disease of unknown etiology. There have been a number of clinical studies to evaluate the usefulness of N-acetylcysteine for the treatment of IPF, but these have produced conflicting results.

Similarly, systemic enzymes such as serrapeptase and nattokinase have also been tried with varying degree of results. Hence, it would be advisable to clarify their use in your condition by consulting Pulmonologist before taking such medications.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Ashakiran S,
General & Family Physician
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Can N-Acetylcysteine And Nattokinase Be Taken For Idiopathic Pulmonary Fibrosis?

Hi, Nattokinase is an enzyme extracted and purified from a Japanese food called nattō, which is made from fermented soybeans. It exhibits a strong fibrinolytic activity. It thins the blood and helps break up blood clots. It intake is possibly effective for high blood pressure as some research suggests that taking nattokinase daily for up to 8 weeks can reduce blood pressure in people with hypertension. N-acetylcysteine is a medication used to loosen thick mucus in individuals with cystic fibrosis or with chronic obstructive pulmonary disease. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, interstitial lung disease of unknown etiology. There have been a number of clinical studies to evaluate the usefulness of N-acetylcysteine for the treatment of IPF, but these have produced conflicting results. Similarly, systemic enzymes such as serrapeptase and nattokinase have also been tried with varying degree of results. Hence, it would be advisable to clarify their use in your condition by consulting Pulmonologist before taking such medications. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Ashakiran S, General & Family Physician