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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Oxycodone And Methadone Be Taken Together?

I have been taking pain medications for a number of years. Currently Methadone HCL 10mg tabs, 4 tablets 3 times a day and Oxycodone HCL 30mg tabs,1 tablet by mouth every 6 hours as needed for pain. My question is with my Methadone being long term released is it possible to get Oxycodone in Instant Relief? Currently both are generic with Mfg.: CARACO and MAYNE PHARMA the two my pharmacy fills from. If my Oxydone cannot fill using IR from generic can I ask them to fill using a non-generic Mfg.?
Thu, 20 Sep 2018
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General & Family Physician 's  Response
Hi,

Two opioids cannot be taken together as they may cause respiratory depression. You can take one-sixth of the dose of Oxycodone for breakthrough pain.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Rana Ahsan Javed,
General & Family Physician
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Can Oxycodone And Methadone Be Taken Together?

Hi, Two opioids cannot be taken together as they may cause respiratory depression. You can take one-sixth of the dose of Oxycodone for breakthrough pain. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Rana Ahsan Javed, General & Family Physician