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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Oxycodone Be Taken 2 Hours After Taking Hydrocodone?

Hello my fiance just had surgery this morning. On Tuesday prior to surgery he was prescribed hydrocodone/acetaminophen 5-325. He has been taking them as prescribed. Today after surgery he was prescribed oxycodone 5mg. The question is he just took a hydrocodone approx 2 hours ago, we just picked up his prescription of oxycodone he is still in a lot of pain can he take a oxycodone now or does he need to wait a certain length of time?
Thu, 16 Apr 2020
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General & Family Physician,  's  Response
Hi.

It is not advisable to give oxycodone 2 hours after taking hydrocodone. Taking opioid analgesics like hydrocodone and oxycodone together at a short interval can cause central nervous system depression which can lead to serious side effects including respiratory distress, coma, and even death.

Talk to his doctor to prescribe alternatives like anti-inflammatory drugs that do not interact, or he may need a dose adjustment or more frequent monitoring to safely use both medications.

Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Mohammed Taher Ali, General & Family Physician
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Can Oxycodone Be Taken 2 Hours After Taking Hydrocodone?

Hi. It is not advisable to give oxycodone 2 hours after taking hydrocodone. Taking opioid analgesics like hydrocodone and oxycodone together at a short interval can cause central nervous system depression which can lead to serious side effects including respiratory distress, coma, and even death. Talk to his doctor to prescribe alternatives like anti-inflammatory drugs that do not interact, or he may need a dose adjustment or more frequent monitoring to safely use both medications. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician