Hello, Seroquel which is also known as quetiapine, is an antipsychotic medication. It is primarily used to treat bipolar disorder and schizophrenia. While oily skin is not a common side effect of Seroquel, it is possible that the medication could cause changes in the skin. Seroquel can cause a range of side effects, including dizziness, drowsiness, dry mouth, and constipation. However, there are no known reports of Seroquel causing oily skin. Other factors, such as changes in hormone levels or dietary factors, could also contribute to changes in skin oiliness. If you continue to experience oily skin while taking Seroquel, it is recommended that you speak with your healthcare provider to rule out any other potential causes and determine if any changes to your treatment plan are necessary. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. H. Kay, General & Family Physician