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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Eptoin Cause A Reaction Leading To Skin Rash And Itch?

HI Doctor.. my husband had a Eptoin 100 MG reaction( drug reaction). due to which he was hospitalized. During the Drug reaction he developed skin rash and Skin itch ..its almost 2 months completed and yet he is suffering because of the skin itching. Pls advice om his aliment
Mon, 30 Jun 2014
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Psychiatrist,  's  Response
hi thanks for your query.your husband seem to suffer from drug induced skin rash.....rarely it can lead to
"Phenytoin Hypersensitivity Syndrome Presenting as Multi-System Organ Failure"
Phenytoin hypersensitivity syndrome (PHS) is a reaction which typically develops within 3 weeks to three months after initiation of treatment with phenytoin.

It is characterized by fever, exanthems that range from acneiform to erythema multiforme major, lymphadenopathy, and eosinophilia .

In addition, patients may develop hepatitis and acute renal failure.
IT IS ONCE FOR ALL SUGGESTED THAT YOUR HUSBAND STOPS THE OFFENDING DRUG WITH AN IMMEDIATE EFFECT.
STEROIDS,ANTIHISTAMINICS CAN BE USED IN THE MANAGEMENT OF THIS RASH.
MOST IMPORTANT A SUITABLE ALTERNATIVE OF VALPROIC ACID CAN BE INSTITUTED TO YOUR HUSBAND.KINDLY CONSULT YOUR NEUROLOGIST AS HIS SUBSTITUTION SHOULD BE DONE UNDER EXPERT CARE.
THANK YOU.
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Can Eptoin Cause A Reaction Leading To Skin Rash And Itch?

hi thanks for your query.your husband seem to suffer from drug induced skin rash.....rarely it can lead to Phenytoin Hypersensitivity Syndrome Presenting as Multi-System Organ Failure Phenytoin hypersensitivity syndrome (PHS) is a reaction which typically develops within 3 weeks to three months after initiation of treatment with phenytoin. It is characterized by fever, exanthems that range from acneiform to erythema multiforme major, lymphadenopathy, and eosinophilia . In addition, patients may develop hepatitis and acute renal failure. IT IS ONCE FOR ALL SUGGESTED THAT YOUR HUSBAND STOPS THE OFFENDING DRUG WITH AN IMMEDIATE EFFECT. STEROIDS,ANTIHISTAMINICS CAN BE USED IN THE MANAGEMENT OF THIS RASH. MOST IMPORTANT A SUITABLE ALTERNATIVE OF VALPROIC ACID CAN BE INSTITUTED TO YOUR HUSBAND.KINDLY CONSULT YOUR NEUROLOGIST AS HIS SUBSTITUTION SHOULD BE DONE UNDER EXPERT CARE. THANK YOU.