Hello, Thanks for your query. Ibuprofen are available without a prescription, but you should ask your doctor about taking them. They may reduce the amount of opioid analgesic you need, possibly reducing side effects such as nausea, vomiting, and drowsiness. If taken alone, there are no restrictions on driving or operating machinery. You should not take these drugs without your doctor s approval if you have kidney problems, a history of stomach ulcers, heart failure or are on blood thinner medications such as Coumadin® (warfarin), Lovenox® injections, or Plavix®. I do hope that you have found something helpful and I will be glad to answer any further query. Take care