I have been taking 25mg of seroquel, prescribed as a sleeping aid, for 8 years. A year and half ago I was diagnosed with rheumatoid arthritis (rheumatoid factor, increased RNP, increased anti-smith). Rheumatologist tried plaquenil, then sulfasalazine, all with no success. I am now trying Cellcept. I have been on prednisone since first diagnosed and am up to 10mg. Could the Seroquel be causing my swelling, joint pain, and severe fatigue? Age-47, height 6 2 , weight185lbs. No other health issues. I exercise regularly and do not drink, smoke, or take recreational drugs.