I have a hysterectomy scheduled for September 24, 2014. Doctor started me on 3 months of Lupron injections to shink a large fibroid, so we could do it laparoscopically. My second Lupron shot was one week late, the third and final shot, 15 days late- due to insurance and communication issues within my doctor s office. I am having severe pain from fibroid. Doctor performed a manual exam last week, and told me the fibroid did not shrink. She says it has nothing to do with the shots being late. I m not convinced. Can you adequately tell if the fibroid did or didn t shrink with a manual exam? (MRI and ultrasound tests were done in May, prior to Lupron therapy) But no imaging since.