I am on methadone (opoid pharmacotherapy) and experience chronic constipation. I have tried lactulose, glycerin suppositories, and microlax but I am still not regular enough and look sickly and pallid, and experience intense fatigue and brain fog after the 5th day of not doing a number 2. I eat 1-2 meals consisting wholly of fresh fruit per day, plus I do 45 minutes of vigorous Ashtanga yoga an average of 6 days per week, with lots of walking as part of my lifestyle. What should I do? Also, I know that aloin is an effective laxative. Is it safe to use every day over the long term? What about senna? I have heard that any stimulant laxative is not safe to use daily ove the long term. Is that correct?