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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Taking Excedrin Along With Zzzquil Be Safe?

Is it safe to take excedrin and generic zzzquil together? I had a bad headache so I took some excedrin and then not too long after that I decided to go to bed and took some generic zzzquil without even thinking about if it would react until after I took them.
Fri, 10 Jun 2016
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General & Family Physician 's  Response
HI, thanks for using healthcare magic

There are different formulations of excedrin. It may contain acetaminophen, aspirin or/and caffeine.

Caffeine decreases sedation and zzzquil increases sedation, this may not have any effect at all but it is the only known interaction between these agents.

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Can Taking Excedrin Along With Zzzquil Be Safe?

HI, thanks for using healthcare magic There are different formulations of excedrin. It may contain acetaminophen, aspirin or/and caffeine. Caffeine decreases sedation and zzzquil increases sedation, this may not have any effect at all but it is the only known interaction between these agents. I hope this helps