Can Plavix cause an increase in ESR? I am 56, 5 10 , 170lbs, very fit and low body fat. Just had rotator cuff surgery, reacted to pain pills, got some numbness in face (have had for a year, lack of sleep, issues stemming from murder of son and divorce, etc.). Dr. prescribed Plavix for possible TIA, CatScan and thyroid ultrasound showed 2 small bumps on thyroid, blook test shows ESR 50 vs normal range of 0-20. All other test normal or on border of normal range except lymphocyles which is 8 vs. normal range of 13-44.