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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Child Have High SGOT And SGPT Levels. Test Negative For Virus And Suggested To Have Liver Defects. Advise?

Hi ,
My son aged 2.7 Years have high levels of SPOT 349 and SPGT 490 since last one year, doctor's have done lot of test for the virus and all have come negative, one doctor is suggesting in born liver defect test and the other doctor suggests liver biospy, can you please suggest the possible causes for this and which approach need to be followed ??
Sat, 21 Sep 2013
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Radiologist 's  Response
Hello
Thanks for writing to HCM
There may be various causes for increased SGOT and SGPT in this age group.
It should be investigated in a systematic way .You didn’t mentioned about other parameters of LFT.
Besides clinical examination he needs routine hemogram, complete LFT,RET,urine RE/ME,ultrasound of abdomen and CT Scan ,MRI can be done if needed.
Causes may be hepatitis,metabolic disorders,cystic fibrosis,cardiomyopathy etc.
Treatment depends upon clinical findings and investigations reports.
Get well soon.
Take Care
Dr.Indu Bhushan
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General Surgeon Dr. Dr. Ivan Romich's  Response
Hi and welcome to HCM. Thanks for the query.
there are few possible causes and most of them are benign seuch as gilberts syndrome. Since he is child,the first thing toi think of is congenital liver enzymes defect and born liver tests may rule out these so you should do it first and then plan liver biopsy which is invasuve test and shouldnt be first duagnoistic choice.
Wish you good health. Regards
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Child Have High SGOT And SGPT Levels. Test Negative For Virus And Suggested To Have Liver Defects. Advise?

Hello Thanks for writing to HCM There may be various causes for increased SGOT and SGPT in this age group. It should be investigated in a systematic way .You didn’t mentioned about other parameters of LFT. Besides clinical examination he needs routine hemogram, complete LFT,RET,urine RE/ME,ultrasound of abdomen and CT Scan ,MRI can be done if needed. Causes may be hepatitis,metabolic disorders,cystic fibrosis,cardiomyopathy etc. Treatment depends upon clinical findings and investigations reports. Get well soon. Take Care Dr.Indu Bhushan