I was having a lot of serious issues with depression, joint aches and pain, neck stiffness and pain, poor concentration, dreadful anxiety and no interest in life. I had been on Avapro for 4 years during which time these symptoms were extreme. Many blood tests, x-rays, MRIs did not provide a diagnosis. I ran out of Avapro medication and during the time I was without it in my system I noticed within a short space of time the before mentioned symptoms reduced significantly. The depression and anxiety lifted for the first time in years and I m back involved with life with great energy and achieving goals. Am i right in blaming Avapro for the debilitating symptoms? The only change i have made to my day to day living has been stopping the use of Avapro. Everything else has remained the same.