I have been taking 3 milligrams of roprinole for restless leg syndrome about 10 years now. I do not take it at bedtime as I have a difficult time with RLS in the early evening. I also seem to be lethargic like I am half asleep but can comprehend still. Sometimes it is worse after a heavy evening meal. I am 60 years old 5 11 and about 75 lbs overweight. I don t smoke or drink. I get physicals every 6 months and informed the doctor about how I feel in the early evenings especially after I eat and when I take the medicine later. He said that the heavy meals will make you sleepy. I am also taking: 10 mg of Zeita/ 40mg of Nexium/ 10mg of a generic Lexapro 10mg blood pressure medicine Will these combinations cause these side effects in the evening and this RLS is very miserable and is now starting to effect me when I drive in a car for a long distance. My legs feel jumpy and ache. I am at the point where I have considered asking for a mild muscle relaxer when I have to travel long distances in a car. Please give me an answer.