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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could Taking Omeprazole Cause High ALT Levels In LFT?

Hi I have been taking omeprazole 20mg tablets last 5 months of my pregnancy for preventing extreme heart burn. I recently has liver function test carried out and my alt levels are 211. Consultant will check Nile acids in blood to rule out oc during pregnancy. Would omeprazole be cause for this high alt reading? If I stop would my liver functions get better? Thank you
Thu, 3 Nov 2016
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General & Family Physician,  's  Response
Hello dear
I understand your concern
Omeprazole on long term use damage the liver and cause increase in the Liver enzyme, ALT.
Omeprazole is extensively metabolized by the hepatic P450 system and cause damage to the heart like hepatic necrosis.
The mild and asymptomatic elevations in serum aminotransferase that have been observed during omeprazole therapy are usually transient and may resolve even without dose modification.
Clinically apparent liver injury due to omeprazole, however, generally calls for prompt withdrawal of the agent.
Severe injury due to omeprazole is uncommon and most cases resolve promptly upon withdrawal.
So do not worry, once you stop the drug your liver function will get better.
Hope this may help you

Contact HCM for further health query
Best regards
Dr. Sagar
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Could Taking Omeprazole Cause High ALT Levels In LFT?

Hello dear I understand your concern Omeprazole on long term use damage the liver and cause increase in the Liver enzyme, ALT. Omeprazole is extensively metabolized by the hepatic P450 system and cause damage to the heart like hepatic necrosis. The mild and asymptomatic elevations in serum aminotransferase that have been observed during omeprazole therapy are usually transient and may resolve even without dose modification. Clinically apparent liver injury due to omeprazole, however, generally calls for prompt withdrawal of the agent. Severe injury due to omeprazole is uncommon and most cases resolve promptly upon withdrawal. So do not worry, once you stop the drug your liver function will get better. Hope this may help you Contact HCM for further health query Best regards Dr. Sagar