Hi, Vyvanse is unlikely to cause migraines. Vyvanse (amphetamine derivative) commonly prescribed to treat attention deficit hyperactivity disorder. Its most common side effects include decreased appetite, insomnia, dry mouth, feeling irritable or anxious, dizziness, nausea or vomiting. The exact cause of migraines is not known. There are certain triggers such as lack of sleep, skipping a meal, caffeine or alcohol, and being under stress, sensory stimulation like unusually bright lights, loud noises, or strong smells, hormonal changes or while on birth control pills may also cause recurring migraines. Avoid those triggers and consult your treating doctor if there is no relief. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Mohammed Taher Ali, General & Family Physician