Hi-I am slowly, and I mean slowly recovering from a total, open hysterectomy. I had severe endometriosis along with 2 abdominal masses removed. From what they tell me it was about a 5 hour major surgery. I have had ITP since I was 18. I am 42 now. I have never had to have any kind of major surgery so my ITP was and never has been a factor. I had the IVIG infusions which worked and make my platelet count go up. They were 66,000 and would not operate. Once that was taken care of, my blood pressure became a factor and had to meet with a cardiologist. So, the wait to get my blood pressure under control my platelets took another crash dive. Long story short, I have been on the NPlate injections for 5 solid weeks. I have had severe leg pain. From my knees down, it stings and burns like pine needles pricking me. Numbing pain that hurts really bad. It dawned on me it could be the Nplate injections. Could this be a possibility? I am also a diabetic so was told by my surgeon it could be diabetic nerve pain and would eventually go away. I am due to meet with my hemotologist next week and want to stop the injections. My platelets were at 242,000 today so hoping I can get off the injections. Thanks in advance for your reply.