HI, thanks for using healthcare magic Sickle cell anemia is called this because the red blood cells adopt a sickle shape. In this shape they obstruct the normal flow of blood and result in decreased blood supply to some areas, this can result in a painful crisis. There are different triggers for a crisis. There are: dehydration- he must always drink enough fluids Infection and fever- if possible he needs to be protected from repeated infections by hand washing and persons observing hygienic techniques when they may have infections like the common cold Cold environment- he should be kept warm Bleeding Antibiotics are not known to cause a crisis. I hope this helps